Much of the trouble stems from the use of nations as proxies for cultural units, said Gjerde. "Class differences are typically neglected and the perspective of subordinate groups is therefore overlooked." "Psychologists often speak about the power of culture as an independent variable, but they fail to pay attention to the power structures that frame culture," said Gjerde. In the current issue of the influential journal Human Development, a professor at the University of California, Santa Cruz, challenges his colleagues to reconsider popular ideas about the role of culture in human development.Ĭontemporary scholarship is rife with broad, distorted generalizations about "culture" that play into stereotypes and threaten to obscure the powerful influences that individuality, resistance, and power play in development, said psychology professor Per Gjerde, who contributed the invited lead article to the journal's issue focused on "The Study of Diversity: Human Development in Culture." "Emphasis on 'culture' in psychology fuels stereotypes, scholar says
0 Comments
Sound confusing? It is all explained simply and clearly, and gives little examples and activities for practice. The first chapter explains what analysis is and isn't, and claims that analysis can be broken down into 5 steps: 1) suspend judgment, 2) define significant parts and how they are related, 3) make the implicit explicit, 4) look for patterns, and 5) keep reformulating questions and explanations. (Side note: is this a West-Coast/East-Coast thing? A push away from classical or rhetorical and more of an emphasis on science/social science writing?) I was mostly trained up in writing-across-the-disciplines myself, and sorta taught myself bits of rhetorical analysis and Toulmin, so the WAD argument (hehe, WAD! snicker) makes sense to me. So why is it useful? As people have pointed out in the comments of previous posts, college students don't really write classical rhetorical essays in their classes, and they will write essays in a lot of different disciplines besides English literature. I would get my own copy but I'm tight on money right now, but I'm writing up this post as much as a reminder for me as a recommendation. The drawback to a quick go-through, of course, is that I am seeing all sorts of useful ways of approaching analysis, and interesting ideas for restructuring assignments, but not really anything to throw in to the middle of a semester - it would be worthwhile to take the time of sitting down and reading it slowly and in depth while recreating a syllabus, or even for ordering and using in a course. I ILL'd it and need to give it back soon, so I'm doing a quick go-through, and hence, a very rough preliminary review for you all. In regards to your research projects, I strongly recommend Chapter 9, “Making a Thesis Evolve” for its explanation of what a strong thesis does (not “is” but DOES) and step-by-step tips in developing a working thesis for a research project.Remember how I was complaining about how to teach larger essay structures and not use the 5-p essay format? Someone suggested the textbook, Writing Analytically, by David Rosenwasser and Jill Stephen. This book is an excellent resource to consult for every stage of the research process, from understanding readings and formulating research topics to constructing an argument and using data. If you find this chapter helpful, you can find a PDF of Writing Analytically in the Course Materials GDrive Folder. An added benefit is that the “toolkit” of exercises described in the chapter can be applied to any of the readings in your classes. The immediate benefit of reading this chapter (and using the exercises) is to help you understand the ideas of the texts, find common ideas or patterns of analysis, and then creating open-ended discussion questions for the class. This short chapter contains some great tips for analyzing texts – I particularly like the exercise “The Method” on pages 37-39 and the follow-up tips in using the results of The Method to generate ideas. If you need some help understanding an assigned reading and this formulating some discussion questions for class, I strongly suggest reading Chapter 3, “A Toolkit of Analytical Methods,” from Writing Analytically by David Rosenwasser and Jill Stephens, 5th edition (embedded below, also available in the Course Materials GDrive Folder). Panoramic sunroofs introduce added complexity to a vehicle. While this may sound like a similar issue to the weight factor I mentioned above, it is an important issue to consider in its own right. Having a panoramic sunroof fitted to your vehicle could be the equivalent of having an additional passenger in your car – permanently. The reason they weigh so much is due to glass being a heck of a lot thicker and heavier than steel or aluminium roof panels, not to mention all the additional reinforcing bars, electric motors and drainage channels required. So it doesn’t take a rocket scientist to work out that a 100kg+ (220lb+) glass roof running across the very top of the vehicle isn’t exactly the best idea. Where possible, they also try to position heavy items (such as the engine, gearbox and fuel tank) as low as possible, in order to improve vehicle stability and handling. You’ve been warned!Ĭar manufacturers work hard to reduce the weight of their vehicles as it pays dividends when it comes to acceleration, braking and fuel economy. So if you’re rather tall, you definitely should test the seating position in a panoramic sunroof equipped vehicle before you decide to order or purchase one. The only other alternative for tall drivers is to recline their seat back further in an attempt to gain more headroom, but this can create ergonomic issues relating to steering wheel and pedal reach. Put simply, taller drivers would have to tilt their head on an angle towards the centre of the car in order to have their head positioned within the panoramic roof opening, and clear the headliner. Retracting the sunshade or opening the sunroof often doesn’t fix the issue, either, as the opening itself doesn’t go far enough across in relation to where the driver’s head is located. Sometimes the difference can be as much as 50mm (2 inches). You see, the additional space required for the panoramic sunroof’s motor mechanism and sunshade rollers means that your car will most likely have less headroom compared to if you went without it. Now we wouldn’t blame you for thinking that optioning a panoramic sunroof in your vehicle would give you more headroom, but this simply isn’t the case. This heat can radiate through into the cabin for quite some time after you’ve entered the vehicle and started driving, meaning your vehicle’s air-conditioning system has to work a lot harder to bring the cabin back down to a comfortable temperature and then maintain it. The retractable cloth sunshades fitted directly below the panoramic sunroof do prevent some of this heat from transferring down into the cabin, but this also means that an incredible amount of heat will build up in the space between. Tinted glass works on the principle of absorbing UV rays directly instead of allowing them to pass through into the interior, and essentially creates a large, black, super-heated element across the top of the vehicle. You’d think tinted glass would help somewhat, but sadly in our experience it makes little difference. On days like that, leaving any vehicle out in the sun for 15 minutes or more will see interior temperatures sky-rocket, but a panoramic sunroof equipped car will obviously be the hottest of the lot, because the heat from the sun overhead essentially has a direct path in. Here in Australia, we regularly see summer daytime temperatures in excess of 40c (104f), combined with crystal clear blue skies allowing the strength of the sun to reach simply murderous levels. The severity of this issue depends on your location in the world, how hot the summer temperatures are, and also the clarity of the sky – which will determine how strong the sunlight is. This might seem obvious, but a panoramic sunroof creates a massive window (literally) through which heat from the sun can enter your vehicle. Most people would tend to agree with how good they look, but having owned a panoramic sunroof equipped vehicle for the past 3 years or so, I feel there are some important issues which new car buyers need to consider before they tick that particular box on the options list. I especially like the contrast between the dark roof and lighter paint colours, such as a beautiful snow white-pearl or light silver metallic. Whether you’re looking at the new Mercedes-Benz C-Class or a Kia Stinger, vehicles equipped with full black tinted glass roofs simply look the business. There’s nothing I love more than the look of a vehicle with a panoramic sunroof. Also, it allows adding notes to the screenshots. Snipping Tool captures entire screenshots and enables you to design custom and window-specific snips. With multiple colored pens, an eraser, and a highlighter, the Snipping Tool allows image editing. You can capture a screenshot of your screen using the Snipping Tool followed by intonation, the snips with a mouse and you can email them. Snipping Tool is an application included in Windows OS. These applications may differ in screenshot size, quality, supported operating systems, file format types. With many tools available for taking screenshots, it’s better to look for the free, easy to use, and save a lot of your time during work. Error detection and showcasing is easy with screenshots.Project demonstration process is vivid with screenshots.Collaboration with team members is more straightforward via screenshots.Screenshots allow you to record any information on the screen and save them in image formats of choice. Good screenshot software is mandatory in your Windows toolkit, which may differ from other operating systems. These applications may differ in screenshot size, quality, supported operating systems, file format types, etc. Screenshots allow you to record both funny and crucial information and document problems to show others. Screenshots are essential for onsite work and add more value to remote workers, and Screenshots are handy to detect unusual things on the screen or present mock-up design plans.Ī good screenshot software is a necessity in your Windows toolkit. The primary purpose of taking a screenshot is to capture the errors during work. While taking screenshots was not very common in the previous years, the office work demands screenshots for which you require apps and tools for different operating systems, including Windows. Hackers can use this backdoor to take control of your computer, copy data from your computer or to use your computer to distribute viruses and spam to other people.The latest work scenario demands taking screenshots as a part of daily work. These infections might corrupt your computer installation or breach your privacy.Ī keygen or key generator might contain a trojan horse opening a backdoor on your computer. Simple Screenshot Capture Software 7.0 download. While you are searching and browsing these illegal sites which distribute a so called keygen, key generator, pirate key, serial number, warez full version or crack for Your computer will be at risk getting infected with spyware, adware, viruses, worms, trojan horses, dialers, etc Including Rapidshare, HellShare, HotFile, FileServe, MegaUpload, YouSendIt, SendSpace, DepositFiles, Letitbit, MailBigFile, DropSend, MediaMax, LeapFile, zUpload, MyOtherDrive, DivShare or Simple Screenshot Capture Software 7.0 torrent files or shared files from free file sharing and free upload services, Download links are directly from our mirrors or publisher's website, Simple Screenshot Capture Software 7.0 license key is illegal and prevent future development of Using warez version, crack, warez passwords, patches, serial numbers, registration codes, key generator, pirate key, keymaker or keygen for Top 4 Download periodically updates software information of Simple Screenshot Capture Software 7.0 full version from the publisher,īut some information may be slightly out-of-date. Gameplay is quite simple, yet requires skill to master. Gameplay aspects carried over from Scorched Earth In contrast, the apocalypse mod which recent versions of Scorched 3D come with adds a lot of original gameplay elements. The core mode aims strongly to stay true to the original gameplay formula of Scorched Earth. Version 43 also has quickened the gameplay, and there is a completely new mod added: AWE (Armored Warfare Evolved) Gameplay The current stable version is v43 which streamlines and improves the playing experience. It was eventually converted into a game, early on, and development continues to this very day with the project being hosted by. Scorched 3D originally started as a 3D landscape generator. I thought that Scorched in 3D would allow many more game concepts, and also combined my love of 3D graphics with the classic game. Recently on a boring flight I played it with friends for eight hours straight we hardly noticed the time passing. On many nights we used to play the game while drinking - although it is pretty good even without the drink. Scorched Earth was an institution for me and my friends at university. The idea for the creation of Scorched 3D was revealed in an interview with Gavin on The O'Reilly Network: The first build was created in April 2001 by lead developer Gavin Camp.
The app was developed by Shifty Jelly, a company in Adelaide, Australia. But now that PocketCasts is free I can just tell them to go straight to my favorite podcatcher! When I introduce new people to podcasting I find they are hesitant to buy an app so I tell them to use Apple Podcasts, Google Podcasts or another free podcast app. I think this new freemium pricing model is a great move for PocketCasts. If these features apeal to you then the low cost of upgrading to PocketCasts Plus may be worth it. This is cool.Īnd if you are bored of the light, dark and extra dark options in PocketCasts you can now customize the look of the app to your own liking by choosing your own colors and icons. If you have your own media files like keynote speach recordings from conferences, ebook recordings, webinar recordings or any other sources you can now upload them into your PocketCasts account and access them through PocketCasts. PocketCasts remembers where you left off! Just like switching between Android and iOS apps. You can listen to the Android or iOS PocketCasts app while commuting to work and then switch to the desktop web app and continue your episode on your computer. PocketCasts Desktop app was previously sold as a separate app but is now included with PocketCasts Plus.
The compensation we receive from advertisers does not influence the recommendations or advice our editorial team provides in our articles or otherwise impact any of the editorial content on Forbes Advisor. Second, we also include links to advertisers’ offers in some of our articles these “affiliate links” may generate income for our site when you click on them. This site does not include all companies or products available within the market. The compensation we receive for those placements affects how and where advertisers’ offers appear on the site. First, we provide paid placements to advertisers to present their offers. This compensation comes from two main sources. To help support our reporting work, and to continue our ability to provide this content for free to our readers, we receive compensation from the companies that advertise on the Forbes Advisor site. The Forbes Advisor editorial team is independent and objective. NordVPN is intuitive to use, easy to set up and reliable and its plans-while higher priced than some competitors-are affordable and aligned with its comprehensive service. The company specifically caters to businesses and teams with affordable monthly plans and uses thousands of servers around the world to facilitate high-speed encrypted internet activity. However, if you want a VPN for business- or work-related use, we recommend NordVPN over IPVanish and Surfshark. The company also uses more than 75 server locations around the world, so you can count on less downtime than with most competitors. The company also has servers in more than 75 locations around the world. It’s compatible with most operating systems and lets you use the VPN on unlimited devices. If you’re looking for an affordable way to add security to your internet activity at home, IPVanish likely has everything you need. However, NordVPN limits your number of devices to just six, has fewer server locations than many competitors and is one of the more expensive VPNs, so you have to balance cost with your needs to choose the right service for you. NordVPN is the only of these three services to offer a dedicated IP option and business plans, and it’s compatible with more devices, so it’s the most robust of all the services. Keep in mind that these prices are for the first year only. IPVanish currently has a promotion offering its VPN at $47.89 a year while Surfshark has its VPN on sale for $47.88 per year. Android, iOS, Windows, Mac, Linux, Android TV Whenever possible, primary AML cells were maintained at high density (5−10 × 10 6 cells/mL) and the medium was changed every second day. Primary AML cells were cultured in StemSpan Serum-Free Expansion Medium II (STEMCELL Technologies, Vancouver, BC, Canada) containing L-Glutamine (2 mM), Penicillin/Streptomycin (50 U/mL), the cytokines Flt3-Ligand (50 ng/mL), TPO (50 ng/mL), SCF (100 ng/mL) and IL-3 (20 ng/mL) (all from PeproTech Inc., Cranbury, NJ, USA) and the compounds StemRegenin1 (500 nM) and UM729 (50 nM) (both from STEMCELL Technologies, Vancouver, BC, Canada). All cell lines were kept at 37 ☌ and 5% CO 2 and were split twice a week. HEK293T and HeLa cells were cultured in DMEM (Gibco TM Thermo Fisher Scientific, Waltham, MA, USA) supplemented with Penicillin/Streptomycin (50 U/mL) and 10% FBS. The leukemic cell line SET-2 was maintained in RPMI (Gibco TM Thermo Fisher Scientific, Waltham, MA, USA) supplemented with Penicillin/Streptomycin (50 U/mL) and 20% heat-inactivated FBS. The leukemic cell line OCI-AM元 was maintained in Alpha-MEM (Biochrom AG, Berlin, Germany) supplemented with L-Glutamine (2 mM Invitrogen TM Thermo Fisher Scientific, Waltham, MA, USA), Penicillin/Streptomycin (50 U/mL Invitrogen TM) and 20% heat-inactivated FBS (Gibco TM Thermo Fisher Scientific, Waltham, MA, USA). Here, we describe a high-throughput RNAi-based screening approach to functionally profile primary DNMT3A WT/R882X cells from AML patients. Previous work from our lab has shown that high-throughput genetic screens in primary AML cells are feasible and a powerful tool to nominate patient-specific targets. While AML cell lines largely reflect the cytogenetics of the original malignancy, the transcriptional and epigenetic profiles of cancer cell lines may differ dramatically from those of primary cancer cells. Nevertheless, confirming these dependencies in patient-derived material remains a challenging task, exposing the drawbacks of cell lines as AML models. Genetic screens in cancer cell lines have been used to identify cancer vulnerabilities and in recent years very comprehensive databases of such vulnerabilities have been generated. High-throughput genetic screens are a well-established technique for revealing genotype–phenotype connections. Thus, there is a clinical need for discovering vulnerabilities of this cell population that can be exploited as a therapeutic approach. The mutant DNMT3A R882X protein induces epigenetic changes in HSCs that distort the balance between self-renewal and differentiation, however detailed knowledge about the downstream targets of these changes remains scarce. Remarkably, AML patients with DNMT3A mutations have shorter survival than DNMT3A WT patients, and this effect seems to be independent of the characteristic late co-mutations in FLT3 or NPM1. Recent studies in primary cells from AML patients have shown that the DNMT3A R882 mutation marks immature cells that are resistant to chemotherapy and represent a reservoir for AML relapse. A prominent example of this is normal karyotype AML (NK-AML) with mutations in DNMT3A. Unlike leukemic blasts that harbor several driver mutations, which can potentially be exploited as therapeutic targets (e.g., FLT3-ITD ), leukemic progenitors often lack therapeutically actionable mutated targets. Our results suggest that MDM4 inhibition is a potential target in NK-AML patients bearing DNMT3A R882X mutations. Moreover, we found that the MDM2/4 inhibitor ALRN-6924 impairs growth of DNMT3A WT/R882X primary cells in vitro by inducing cell cycle arrest through upregulation of p53 target genes. We analyzed a publicly available RNA-Seq dataset of primary normal karyotype (NK) AML samples and found a trend towards MDM4 transcript overexpression particularly in DNMT3A-mutant samples. As one of the strongest hits, we identified MDM4 as a gene essential for proliferation of primary DNMT3A WT/R882X AML cells. To unravel therapeutically actionable targets in mutant DNMT3A-driven AML cells, we have performed a focused RNAi screen in a panel of 30 primary AML samples, all carrying a DNMT3A R882 mutation. Currently, there are no therapeutic approaches directed specifically against this cell population. Recent evidence suggests that these mutations arise early in leukemogenesis, marking leukemic progenitors and stem cells, and persist through consolidation chemotherapy, providing a pool for AML relapse. DNA-methyltransferase 3A ( DNMT3A) mutations belong to the most frequent genetic aberrations found in adult acute myeloid leukemia (AML). In retrofit CFLs or LEDs, and even energy-saving halogen lamps, an equivalent incandescent or halogen wattage is given by manufacturers to make life easier. Now that different technologies have entered into the equation, using wattage as an indicator of output has become increasingly obsolete. With incandescent and halogen lighting it was always easy to equate wattage with light output, because the same wattage always produced the same amount of light. This means it contributes to candela just as it contributes to lux at X meters away.Lumen (lm), lux (lx) and candela (cd) are units of measurement used to describe the output of bulbs and light fittings. The spill also follows the inverse square law of light. Third, it is not possible for candela numbers to "be inflated by spill" If you want to know the intensity at 20m then you just do candela / 20^2 = 250 lux So there is nothing wrong comparing lights using the candela value. If a flashlight measured 1000lux at 10m that flashlight is said to have 100k lux at 1m aka 100kcd Second, since candela is literally just a recalculation of the lux, you can convert between the two units whenever you want and they will not change. The lumens and candelas produced by the bulb don't change, but the number of lux entering your eyeball goes way down when you're 100 yards from the bulb.īrightness is perception of light, not an inherent property of any light source.Īnd what kind of hellish combat zones are people living in that they have to go out armed?Ĭlick to expand.Candela numbers are not inflated by spill.įirst of all, nobody measured candela by putting the luxmeter at 1m and taking a measurement, you have to go 10-20m away and take a measurement and then use the inverse square law of light to calculate it back to 1m to get candela.Ī) luxmeters have a limited measurement range that usually only goes up to 20k or 200k lux so you need to be farther away to actually get a measurementī) luxmeters lose precision when measuring higher lux values so again you want to go farther away to have a more accurate lower lux numberĬ) depending on the head diameter of the flashlight the beam is usually not fully formed at 1m, that means the luxmeter will not be reading the full intensity of the flashlight But if that same 1000 watt lamp is the only light working in an entire mall parking lot, it's going to be spooky dim when you're more than a short distance away from it. Stare into a 1000 watt mercury vapor lamp at arm's length, it'll make your eyes water, (because it's so "bright"). Lots of lumens, but spread out - lower candelas, and each surface in the room gets a lower lux share. An old-timey frosted 100 watt incandescent bulb will fill a residential room with comfortable light levels, but the cat will easily spot the laser pointer dot anywhere on the floor. That's like a laser - lots of candelas (intensity) but not much total light power (lumens). You could have a narrow pipe going up a hill to a spring - at the bottom, you'd have lots of pressure, but maybe not much water in the pipe. It's like "gallons" - how much water in the pool? "feet" - how deep is the pool at any point? "gallons per square foot" - how many walls can I cover with this can of paint? Candela - how much power is passing through a point LUx - how much total light power is falling on an area. Measuring light is no harder than measuring liquids. The problem is that we mean so many different things by "brightness" when we use that term, that it's hard to relate that sensation to the numerical measurements. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |